Skin cancer is two steps, and you have only ever been warned about one of them.
Initiation is the mutation. Ultraviolet writes it into a skin cell's DNA.
It writes it into everybody. The Greek fisherman, the Danish clerk, the Cumbrian shepherd.
A mutated cell is not a tumour. It is a cell the immune system finds and kills, thousands of times a summer.
Promotion is whatever stops that happening.
Sunlight on skin releases prostaglandin E2, and prostaglandin E2 tells the immune cells to stand down.
Prostaglandin E2 is made from arachidonic acid.
Arachidonic acid is made from linoleic acid.
Linoleic acid is sunflower oil, rapeseed oil, corn oil, soybean oil, and every spread built from them.
One chain. One entry point. No linoleic acid in the membrane, no prostaglandin surge, no stand-down. The mutated cell dies like the rest.
Switch a transplant patient's immune system off with drugs and their squamous skin cancer risk rises 65-fold. Same sun. Same skin. The guard was removed.
Seed oil removes the guard chemically, every time the sun comes out.
A study took 76 people who had already had a skin cancer and halved the fat in their food. Two years later the control group had grown ten new lesions apiece. The other group had grown three.
Ibuprofen exists to jam the enzyme that turns arachidonic acid into prostaglandin. Regular users get fewer skin cancers. Nobody has ever asked why.
A saturated fat cannot enter that chain at any point. It has no double bond to convert. Beef fat, butter, lamb, dripping: zero.
Your grandmother worked the garden in a housecoat with no cream on, on a membrane built from dripping, and died with her own skin.
Every leaflet in the dermatology waiting room is about initiation. Hats, shade, factor 50.
Nobody in that room has been asked what they built their promotion out of.
The sun writes the mutation. The bottle in the cupboard signs it off.
Mike
Initiation is the mutation. Ultraviolet writes it into a skin cell's DNA.
It writes it into everybody. The Greek fisherman, the Danish clerk, the Cumbrian shepherd.
A mutated cell is not a tumour. It is a cell the immune system finds and kills, thousands of times a summer.
Promotion is whatever stops that happening.
Sunlight on skin releases prostaglandin E2, and prostaglandin E2 tells the immune cells to stand down.
Prostaglandin E2 is made from arachidonic acid.
Arachidonic acid is made from linoleic acid.
Linoleic acid is sunflower oil, rapeseed oil, corn oil, soybean oil, and every spread built from them.
One chain. One entry point. No linoleic acid in the membrane, no prostaglandin surge, no stand-down. The mutated cell dies like the rest.
Switch a transplant patient's immune system off with drugs and their squamous skin cancer risk rises 65-fold. Same sun. Same skin. The guard was removed.
Seed oil removes the guard chemically, every time the sun comes out.
A study took 76 people who had already had a skin cancer and halved the fat in their food. Two years later the control group had grown ten new lesions apiece. The other group had grown three.
Ibuprofen exists to jam the enzyme that turns arachidonic acid into prostaglandin. Regular users get fewer skin cancers. Nobody has ever asked why.
A saturated fat cannot enter that chain at any point. It has no double bond to convert. Beef fat, butter, lamb, dripping: zero.
Your grandmother worked the garden in a housecoat with no cream on, on a membrane built from dripping, and died with her own skin.
Every leaflet in the dermatology waiting room is about initiation. Hats, shade, factor 50.
Nobody in that room has been asked what they built their promotion out of.
The sun writes the mutation. The bottle in the cupboard signs it off.
Mike
